The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies.Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly.Our data demonstrated that MPT0B451 significantly inhibited cancer
Therapy response monitoring in blood plasma from esophageal adenocarcinoma patients using cell-free DNA methylation profiling
Abstract Esophageal adenocarcinoma (EAC) is an aggressive cancer characterized by a high risk of relapse post-surgery.Current follow-up methods (serum carcinoembryonic antigen detection and PET-CT) lack sensitivity and reliability, necessitating a Eye Drops novel approach.Analyzing cell-free DNA (cfDNA) from blood plasma emerges as a promising aven
Oral telangiectatic granuloma with an intrabony defect
Oral telangiectatic granuloma is a benign hyperplastic lesion occurring in response to trauma or chronic irritation in the oral cavity.The characteristic histological appearance comprises of typical granulation tissue with a Shoes - Sandals - Youth proliferation of small thin-walled blood vessels in the loose connective tissue.We describe a case of
geoBoundaries: A global database of political administrative boundaries.
We present the geoBoundaries Global Administrative Database (geoBoundaries): an online, open license resource of the geographic boundaries of political administrative divisions (i.e., state, county).Contrasted to other resources geoBoundaries (1) provides detailed information on Bar Height Stool the legal open license for every boundary in the repo